CK156
CK156, a chemical probe, is a highly selective death-associated protein kinase (DAPK) inhibitor with IC50s of 182 nM,34 μM, and 39 μM in the DRAK1 NanoBRET assay for DRAK1, CK2a1, and CK2a2, respectively. CK156 can be used for the research of autoimmune and inflammatory diseases[1].
Product Specifications
CAS Number
2910938-59-7
UNSPSC
12352005
Target
DAPK
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/ck156.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C2C=C1OCCOCCNC3=NC4=C2C=NN4C=C3)NC(C)(C)C
Molecular Formula
C21H25N5O3
Molecular Weight
395.45
References & Citations
[1]Christian G Kurz, et al. Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5- a]pyrimidine-Based Macrocycles. J Med Chem. 2022 Jun 9;65 (11) :7799-7817.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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