CK156

CK156, a chemical probe, is a highly selective death-associated protein kinase (DAPK) inhibitor with IC50s of 182 nM,34 μM, and 39 μM in the DRAK1 NanoBRET assay for DRAK1, CK2a1, and CK2a2, respectively. CK156 can be used for the research of autoimmune and inflammatory diseases[1].

Product Specifications

CAS Number

[2910938-59-7]

UNSPSC

12352005

Target

DAPK

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/ck156.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C2C=C1OCCOCCNC3=NC4=C2C=NN4C=C3)NC(C)(C)C

Molecular Formula

C21H25N5O3

Molecular Weight

395.45

References & Citations

[1]Christian G Kurz, et al. Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5- a]pyrimidine-Based Macrocycles. J Med Chem. 2022 Jun 9;65 (11) :7799-7817.