Xylocydine

Xylocydine is an inhibitor of CDK1/2, inhibiting CDK function in various apoptotic processes. Xylocydine specifically blocks CDK1 and CDK2 activity with IC50 of 1.4 nM and 61 nM, respectively. In addition, Xylocydine downregulates phosphorylated nucleolin and retinoblastoma protein levels.[1].

Product Specifications

CAS Number

[685901-63-7]

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xylocydine.html

Smiles

O=C(N)C1=C(N([C@H]2O[C@@H](CO)[C@@H](O)[C@@H]2O)C3=NC=NC(N)=C31)Br

Molecular Formula

C12H14BrN5O5

Molecular Weight

388.17

References & Citations

[1]Xylocydine, a Novel Inhibitor of Cyclin-Dependent Kinases, Prevents the Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Apoptotic Cell Death of SK-HEP-1 Cells