Tauro-ω-muricholic acid (sodium)

Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies[1][2]

Product Specifications

CAS Number

[2456348-84-6]

Product Name Alternative

TωMCA (sodium)

UNSPSC

12352211

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tauro-ω-muricholic-acid-sodium.html

Purity

97.80

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

C[C@@H]([C@]1(CC[C@]2([C@@]3([C@H]([C@@H]([C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@@]21C)[H])C)O)[H])O)O)[H])[H])[H])CCC(NCCS(=O)(O[Na])=O)=O

Molecular Formula

C26H44NNaO7S

Molecular Weight

537.68

References & Citations

[1]Zöhrer E, et al. Neonatal sepsis leads to early rise of rare serum bile acid tauro-omega-muricholic acid (TOMCA) .Pediatr Res. 2018 Jul;84 (1) :66-70.|[2]Tang Y, et al. Turnover of bile acids in liver, serum and caecal content by high-fat diet feeding affects hepatic steatosis in rats. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864 (10) :1293-1304