CCT129957

CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM[1][2].

Product Specifications

CAS Number

[883098-58-6]

UNSPSC

12352005

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cct129957.html

Concentration

10mM

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)NCCC3=CC=CC=C3

Molecular Formula

C17H15N3O3

Molecular Weight

309.32

References & Citations

[1]Reynisson J, et al. The identification of novel PLC-gamma inhibitors using virtual high throughput screening. Bioorg Med Chem. 2009 Apr 15;17 (8) :3169-76.|[2]Feng L, et al. The effect of PLC-γ2 inhibitors on the growth of human tumour cells. Eur J Med Chem. 2012 Aug;54:463-9.