(-) -Gallocatechin

(-) -Gallocatechin, an epimer of (-) -Epigallocatechin (EGC), is contained in various tea products. (-) -Gallocatechin has antioxidant activities. (-) -Gallocatechin is the main active component in green tea extract (HTP-GTE) responsible for its effect of improving age-related cognitive impairments involving protein kinase A (PKA) pathway[1][2][3][4].

Product Specifications

CAS Number

[3371-27-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Drug Isomer; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/minus-gallocatechin.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 1.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@H](C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1

Molecular Formula

C15H14O7

Molecular Weight

306.27

Precautions

H315, H319, H335

References & Citations

[1]Takagaki A, et, al. Biotransformation of (-) -epigallocatechin and (-) -gallocatechin by intestinal bacteria involved in isoflavone metabolism. Biol Pharm Bull. 2015;38 (2) :325-30.|[2]Xu JZ, et, al. Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. Br J Nutr. 2004 Jun;91 (6) :873-81.|[3]Ikeda I, et, al. Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate. J Agric Food Chem. 2003 Dec 3;51 (25) :7303-7.|[4]Ahn JW, Kim S, Ko S, Kim YH, Jeong JH, Chung S. Modified (-) -gallocatechin gallate-enriched green tea extract rescues age-related cognitive deficits by restoring hippocampal synaptic plasticity. Biochem Biophys Rep. 2022;29:101201.