20- (tert-Butoxy) -20-oxoicosanoic acid

20- (tert-Butoxy) -20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . 20- (tert-Butoxy) -20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<su

Product Specifications

CAS Number

[683239-16-9]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/20-tert-butoxy-20-oxoicosanoic-acid.html

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(OC(C)(C)C)CCCCCCCCCCCCCCCCCCC(O)=O

Molecular Formula

C24H46O4

Molecular Weight

398.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.