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CP 461

CP-461 (OSI-461) is a selective apoptotic antineoplastic drug (SAAND) by engaging tubulin on colchicine site[1]

Product Specifications

CAS Number

227619-96-7

Product Name Alternative

OSI-461

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cp-461.html

Smiles

O=C(NCC1=CC=CC=C1)CC(C2=CC(F)=CC=C2/3)=C(C)C3=C\C4=CC=NC=C4.Cl

Molecular Formula

C25H22ClFN2O

Molecular Weight

420.91

References & Citations

[1]Dong-Jun Fu, et al. Bioactive heterocycles containing a 3,4,5-trimethoxyphenyl fragment exerting potent antiproliferative activity through microtubule destabilization. Eur J Med Chem. 2018 Sep 5:157:50-61.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Frequently Asked Questions

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