PU3

PU3 is an Hsp90 inhibitor that competes with geldanamycin (GM) and others for the conserved ATP/ADP pocket of Hsp90. PU3 also induces degradation of proteins such as Her2 and inhibits breast cancer cell growth by causing retinoblastoma protein hypophosphorylation, G1 arrest, and cell differentiation. PU3 has the potential to be a cancer inhibitor.[1].

Product Specifications

CAS Number

[352519-21-2]

UNSPSC

12352005

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pu3.html

Smiles

NC1=C2N=C(N(C2=NC=N1)CCCC)CC3=CC(OC)=C(C(OC)=C3)OC

Molecular Formula

C19H25N5O3

Molecular Weight

371.43

References & Citations

[1]A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and di¡erentiation of breast cancer cells