PU3
PU3 is an Hsp90 inhibitor that competes with geldanamycin (GM) and others for the conserved ATP/ADP pocket of Hsp90. PU3 also induces degradation of proteins such as Her2 and inhibits breast cancer cell growth by causing retinoblastoma protein hypophosphorylation, G1 arrest, and cell differentiation. PU3 has the potential to be a cancer inhibitor.[1].
Product Specifications
CAS Number
352519-21-2
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pu3.html
Smiles
NC1=C2N=C(N(C2=NC=N1)CCCC)CC3=CC(OC)=C(C(OC)=C3)OC
Molecular Formula
C19H25N5O3
Molecular Weight
371.43
References & Citations
[1]A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and di¡erentiation of breast cancer cells
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
E53A05887 50 µg
Recombinant Human Chloride Intracellular Channel Protein 4 Protein
Sign In for Pricing
View Details 133493-ML405 100 µL
SLC45A2 (Solute Carrier Family 45 Member 2, 1A1, AIM1, Membrane-associated Transporter Protein, MATP, Melanoma Antigen AIM1, Protein AIM-1, SHEP5) (MaxLight 405) discontinued
Sign In for Pricing
View Details 
AAP63493-100UG 100 µg
Il15ra Peptide - N-terminal region (AAP63493)
Sign In for Pricing
View Details 