G-479

G-479 is the inhibitor for MEK and hERG channel (IC50=14 μM) . G-479 inhibits the proliferation of HCT-116 and A375 with IC50 of 0.049 μM and 0.004 μM. G-479 exhibits good metabolic stability in liver microsomes and good pharmacokinetic characteristics in rats[1].

Product Specifications

CAS Number

[1168092-22-5]

UNSPSC

12352005

Target

MEK; Potassium Channel

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Membrane Transporter/Ion Channel

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/g-479.html

Smiles

O=C(C1=C(NC2=CC=C(I)C=C2F)N3C(C=N1)=CN=C3)NOC[C@H](O)CO

Molecular Formula

C16H15FIN5O4

Molecular Weight

487.22

References & Citations

[1]Robarge KD, et al., Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. Bioorg Med Chem Lett. 2014 Oct 1;24 (19) :4714-4723.