Nonapeptide-1
Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM) . Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively) . Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer[1][2][3].
Product Specifications
CAS Number
158563-45-2
Product Name Alternative
Melanostatine-5
UNSPSC
12352209
Hazard Statement
H302
Target
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nonapeptide-1.html
Purity
99.04
Solubility
H2O : 44.44 mg/mL (adjust pH to 2 with 1 M HCl)
Smiles
Molecular Formula
C61H87N15O9S
Molecular Weight
1206.50
Precautions
H302
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MC1R; MC3R; MC4R; MC5R
Available Sizes
Frequently Asked Questions
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