Nonapeptide-1

Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM) . Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively) . Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer[1][2][3].

Product Specifications

CAS Number

[158563-45-2]

Product Name Alternative

Melanostatine-5

UNSPSC

12352209

Hazard Statement

H302

Target

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nonapeptide-1.html

Purity

99.04

Solubility

H2O : 44.44 mg/mL (adjust pH to 2 with 1 M HCl)

Smiles

O=C(N1[C@@H](CCC1)C(N[C@H](C(N)=O)C(C)C)=O)[C@H](CCCCN)NC([C@H](CC2=CC=CC=C2)NC([C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](CC3=CC=CC=C3)NC([C@H]4N(CCC4)C([C@@H](N)CCSC)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O

Molecular Formula

C61H87N15O9S

Molecular Weight

1206.50

Precautions

H302

References & Citations

[1]Jayawickreme CK, et al. Discovery and structure-function analysis of alpha-melanocyte-stimulating hormone antagonists. J Biol Chem. 1994 Nov 25;269 (47) :29846-54. |[2]Schiöth, H.B., et al. Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31 (6), 565-571 (1997) .|[3]Jiaoquan Chen, et al. Effects of tea polyphenols on UVA-induced melanogenesis via inhibition of α-MSH-MC1R signalling pathway. Postepy Dermatol Alergol. 2022 Apr;39 (2) :327-335.