Betazole

Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. Betazole induces gastric acid secretion and causes an immediate and significant increase in common bile duct pressure. Betazole is used as a diagnostic agent known as histalog for investigating gastric acid secretory capacity[1][2][3].

Product Specifications

CAS Number

[105-20-4]

Product Name Alternative

Ametazole

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/betazole.html

Purity

96.66

Solubility

DMSO : 175 mg/mL (ultrasonic) |H2O : 35 mg/mL (ultrasonic)

Smiles

NCCC1=NNC=C1

Molecular Formula

C5H9N3

Molecular Weight

111.15

Precautions

H315, H319, H320

References & Citations

[1]Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47 (12) :519-521.|[2]Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31 (4) :380-382.|[3]CLAYMAN CB, . A simple oral gastric secretory stimulant (betazole hydrochloride) . JAMA. 1961;175:908-909.