FLT3-IN-4
FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor for treating acute myelogenous leukemia[1].
Product Specifications
CAS Number
2304799-09-3
UNSPSC
12352005
Hazard Statement
H315, H319
Target
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flt3-in-4.html
Purity
99.73
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
C=CCN1C2=NC=NC(N)=C2C(C3=CC=C(NC(NC4=NOC(C(C)(C)C)=C4)=O)C=C3)=C1
Molecular Formula
C23H25N7O2
Molecular Weight
431.49
Precautions
H315, H319
References & Citations
[1]Yuan X, et al. Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia. J Med Chem. 2019 Apr 25;62 (8) :4158-4173.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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