FLT3-IN-4

FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor for treating acute myelogenous leukemia[1].

Product Specifications

CAS Number

[2304799-09-3]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

FLT3

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/flt3-in-4.html

Purity

99.73

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

C=CCN1C2=NC=NC(N)=C2C(C3=CC=C(NC(NC4=NOC(C(C)(C)C)=C4)=O)C=C3)=C1

Molecular Formula

C23H25N7O2

Molecular Weight

431.49

Precautions

H315, H319

References & Citations

[1]Yuan X, et al. Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia. J Med Chem. 2019 Apr 25;62 (8) :4158-4173.