AM-2394
AM-2394 is a structurally distinct glucokinase activator (GKA) . AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.
Product Specifications
CAS Number
[1442684-77-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Glucokinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/AM-2394.html
Purity
99.30
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O=C(NC)NC1=CC(OC2=CC(C)=CN=C2)=C(C3=CC=C(OCC(C)(O)C)N=C3)C=N1
Molecular Formula
C22H25N5O4
Molecular Weight
423.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Dransfield PJ, et al. Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394. ACS Med Chem Lett. 2016 May 23;7 (7) :714-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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