P2X3 antagonist 39
P2X3 antagonist 39 (compound 26a) is a selective P2X3 receptor antagonist with an IC50 value of 54.9 nM. P2X3 antagonist 39 can be used in the study of neuropathic pain model[1].
Product Specifications
UNSPSC
12352005
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/p2x3-antagonist-39.html
Smiles
C[C@@H](NC1=CC(N2CCN(CC2)C(N)=O)=NC3=NC(C4CC4)=NN13)C5=CC=C6C=CC=CC6=C5
Molecular Formula
C25H28N8O
Molecular Weight
456.54
References & Citations
[1]Kim GR, et al. Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy. J Med Chem. 2024 Aug 5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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