P2X3 antagonist 39

P2X3 antagonist 39 (compound 26a) is a selective P2X3 receptor antagonist with an IC50 value of 54.9 nM. P2X3 antagonist 39 can be used in the study of neuropathic pain model[1].

Product Specifications

UNSPSC

12352005

Target

P2X Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/p2x3-antagonist-39.html

Smiles

C[C@@H](NC1=CC(N2CCN(CC2)C(N)=O)=NC3=NC(C4CC4)=NN13)C5=CC=C6C=CC=CC6=C5

Molecular Formula

C25H28N8O

Molecular Weight

456.54

References & Citations

[1]Kim GR, et al. Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy. J Med Chem. 2024 Aug 5.