What is the catalog number for Citronellol?

The catalog number for Citronellol is HY-W010201.

What sizes are available for Citronellol?

Citronellol is available in the following size(s): 500 mg, 10 mM - 1 mL, 1 g, 5 g, 10 g, 25 g, 50 g, 100 g.

How many pack sizes does Citronellol come in?

Citronellol is available in 8 different pack sizes.

Is Citronellol in stock?

Citronellol is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Citronellol?

Citronellol is manufactured by QuantiMol.

What is the estimated delivery time for Citronellol?

Estimated delivery time for Citronellol is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Citronellol?

The safety data sheet for Citronellol is available here: http://file.medchemexpress.com/batch_PDF/HY-W010201/Citronellol-SDS-MedChemExpress.pdf.

Citronellol

Citronellol ((±) -Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis[2][4][6][7].

Product Specifications

CAS Number

106-22-9

Product Name Alternative

(±) -Citronellol; (±) -β-Citronellol

UNSPSC

12352211

Hazard Statement

H315, H317, H319, H401

Target

Apoptosis; Atg8/LC3; Autophagy; ERK; Fungal; Necroptosis; p62; PI3K; Reactive Oxygen Species (ROS) ; TNF Receptor

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/citronellol.html

Purity

98.78

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(CCC=C(C)C)CCO

Molecular Formula

C10H20O

Molecular Weight

156.27

Precautions

H315, H317, H319, H401

References & Citations

[1]Munir S, et al. The Protective Effect of Citronellol against Doxorubicin-Induced Cardiotoxicity in Rats. Biomedicines. 2023 Oct 18;11 (10) :2820.|[2]Shao J, et al. Citronellol Prevents 6-OHDA-Induced Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Parkinson Disease Model of SH-SY5Y Cells via Modulating ROS-NO, MAPK/ERK, and PI3K/Akt Signaling Pathways. Neurotox Res. 2022 Dec;40 (6) :2221-2237.|[3]Sahli F, et al. Autoxidized citronellol: Free radicals as potential sparkles to ignite the fragrance induced skin sensitizing pathway. Food Chem Toxicol. 2022 Aug;166:113201. |[4]Jayaraj RL, et al. Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an in vivo model of Parkinson's disease. Heliyon. 2022 Nov 3;8 (11) :e11434. |[5]Mahmood YS, et al. Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice. J Med Life. 2023 Jul;16 (7) :1057-1061. |[6]Yu WN, et al. Citronellol Induces Necroptosis of Human Lung Cancer Cells via TNF-α Pathway and Reactive Oxygen Species Accumulation. In Vivo. 2019 Jul-Aug;33 (4) :1193-1201. |[7]Pereira Fde O, et al. Antifungal activity of geraniol and citronellol, two monoterpenes alcohols, against Trichophyton rubrum involves inhibition of ergosterol biosynthesis. Pharm Biol. 2015 Feb;53 (2) :228-34.