11-Hydroxycanthin-6-one

11-Hydroxycanthin-6-one, a canthin-6-one (HY-N3536) alkaloid, is an antitumor agent which shows potent cytotoxic activity[1][2].

Product Specifications

CAS Number

[75969-83-4]

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Drug Derivative

Type

Natural Products

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/11-hydroxycanthin-6-one.html

Solubility

10 mM in DMSO

Smiles

O=C1N2C3=C(N=CC=C3C4=C2C=CC=C4O)C=C1

Molecular Formula

C14H8N2O2

Molecular Weight

236.23

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Fukamiya N, et, al. Antitumor agents: LXXXVII. Cytotoxic antileukemic canthin-6-one alkaloids from Brucea antidysenterica and the structure activity relationships of their related derivatives. Planta Med. 1987 Apr;53 (2) :140-3.|[2]Miyake K, et, al. Canthin-6-one alkaloids and a tirucallanoid from Eurycoma longifolia and their cytotoxic activity against a human HT-1080 fibrosarcoma cell line. Nat Prod Commun. 2010 Jan;5 (1) :17-22.