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PF-DcpSi

PF-DcpSi is a mRNA decapping scavenger enzyme (DcpS) inhibitor (IC50: 0.11 nM) . PF-DcpSi (30 mg/kg, i.p.) ameliorates the disease phenotype in a mice model of spinal muscular atrophy (SMA) [1].

Product Specifications

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pf-dcpsi.html

Purity

98.0

Smiles

N#CC1=CC(F)=CC(OCC2=CC=CC3=NC(N)=NC(N)=C23)=C1

Molecular Formula

C16H12FN5O

Molecular Weight

309.30

References & Citations

[1]Gopalsamy A, et al. Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA) . J Med Chem. 2017 Apr 13;60 (7) :3094-3108.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-122604/PF-DcpSi-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-122604/PF-DcpSi-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Phase 1

CAS Number

[2092917-19-4]

Available Sizes

Curated Selection

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