VU0529331
Product Specifications
UNSPSC Description
VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel[1].
Target Antigen
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/VU0529331.html
Purity
99.81
Solubility
DMSO : 5 mg/mL (ultrasonic;warming)
Smiles
O=C(C1=NC=CN=C1)N2CC3=C(N4C=CC=C4)N(C5=CC(C)=C(C)C=C5)N=C3C2
Molecular Weight
384.43
References & Citations
[1]Kozek KA, et al. Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels. ACS Chem Neurosci. 2018 Sep 13.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112705/VU0529331-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112705/VU0529331-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1286725-49-2
Available Sizes
Curated Selection
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