103D5R
103D5R (Compound 15) is an inhibitor for the activation of hypoxia-inducible factor-1 (HIF-1) with an IC50 of 35 µM, through reduction of the HIF-1α protein synthesis. 103D5R inhibits the proliferation of LN229 with IC50 of 26 µM[1].
Product Specifications
CAS Number
[773852-25-8]
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/103d5r.html
Smiles
CC(N1C=NC2=NC=CC=C21)C3=CC=C4C(C=CC(C)(C)O4)=C3OC
Molecular Formula
C20H21N3O2
Molecular Weight
335.40
References & Citations
[1]Nagle DG, et al., Natural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1) . Curr Drug Targets. 2006 Mar;7 (3) :355-69.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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