LY320954
LY320954 is a selective 5-HT2A receptor antagonist, with a Ki of 96 nM. LY320954 potently inhibits Ca2+ influx in the functional assay (EC50 of 35.5 nM) . LY320954 inhibits 5-HT-induced paw swelling in rats, with ED50 of 4.8 mg/kg[1].
Product Specifications
CAS Number
[182633-59-6]
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly320954.html
Smiles
CCCC1=C(O)C(C(CC)=O)=CC=C1COC2=CC=C(/C=N/NC(N)=N)C=C2
Molecular Formula
C21H26N4O3
Molecular Weight
382.46
References & Citations
[1]H U Bryant, et al. A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines. Life Sci. 1996;59 (15) :1259-68.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; α-1 microglobulin
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