FABP4/5-IN-4

FABP4/5-IN-4 (compound E1) is a potent inhibitor of FABP4 and FABP5, with the IC50s of 3.78 μM and 5.72 μM, respectively. FABP4/5-IN-4 plays an important role in metabolism disorder like diabetes mellitus[1].

Product Specifications

CAS Number

[2862795-48-8]

UNSPSC

12352005

Target

FABP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/fabp4-5-in-4.html

Solubility

10 mM in DMSO

Smiles

O=C(CC1=CC(NS(=O)(C2=C3C=CC=CC3=C(OC)C(C4=C(C)C=C(F)C=C4)=C2)=O)=CC=C1F)O

Molecular Formula

C26H21F2NO5S

Molecular Weight

497.51

References & Citations

[1]Yu-Long He, et al. Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus. Eur J Med Chem. 2021 Nov 15:224:113720.