Adenosine-2'-monophosphate

Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway) . Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].

Product Specifications

CAS Number

[130-49-4]

Product Name Alternative

2'-AMP; Adenosine 2'-phosphate; AMP 2'-phosphate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor; Endogenous Metabolite

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/adenosine-2-monophosphate.html

Purity

99.91

Solubility

1 M NaOH : ≥ 100 mg/mL|DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 50 mg/mL (ultrasonic; adjust pH to 7 with NaOH)

Smiles

O=[P](O)(O)O[C@H]([C@@H]1O)[C@@](N2C3=NC=NC(N)=C3N=C2)([H])O[C@@H]1CO

Molecular Formula

C10H14N5O7P

Molecular Weight

347.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Jackson EK, Gillespie DG, Dubey RK. 2'-AMP and 3'-AMP inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors. J Pharmacol Exp Ther. 2011;337 (2) :444‐450.|[2]Newell EA, Exo JL, Verrier JD, et al. 2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors. Brain Res. 2015;1594:27‐35.