ICA-121431
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 μM) .
Product Specifications
CAS Number
313254-51-2
UNSPSC
12352005
Hazard Statement
H302, H319, H413
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ICA-121431.html
Purity
99.35
Solubility
DMSO : ≥ 44 mg/mL
Smiles
O=C(NC1=CC=C(S(NC2=NC=CS2)(=O)=O)C=C1)C(C3=CC=CC=C3)C4=CC=CC=C4
Molecular Formula
C23H19N3O3S2
Molecular Weight
449.55
Precautions
H302, H319, H413
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.1; Nav1.3; Nav1.4; Nav1.5; Nav1.6; Nav1.8
Available Sizes
Frequently Asked Questions
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