Epothilone A

Epothilone A is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers, with a Ki of 0.6-1.4 μM.

Product Specifications

CAS Number

[152044-53-6]

Product Name Alternative

Epo A

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Epothilone_A.html

Purity

99.81

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C[C@]3([H])O[C@]3([H])CCC[C@H](C)[C@H](O)[C@@H](C)C1=O

Molecular Formula

C26H39NO6S

Molecular Weight

493.66

References & Citations

[1]Kowalski RJ, et al. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol (R) ) . J Biol Chem. 1997 Jan 24;272 (4) :2534-41.|[2]Cheng KL, et al. Novel microtubule-targeting agents - the epothilones. Biologics. 2008 Dec;2 (4) :789-811.