RhoA-ROCK-IN-1
RhoA-ROCK-IN-1 (Compound b19) is an inhibitor of RhoA/ROCK. RhoA-ROCK-IN-1 can significantly inhibit cell proliferation, migration, and invasion, while promoting cell apoptosis. RhoA-ROCK-IN-1 demonstrates remarkable anticancer activity by inhibiting the RhoA/ROCK pathway[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; ROCK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rhoa-rock-in-1.html
Purity
98.40
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CS(C2=CC=C(C3=CN(C)N=C3)C=C21)(=O)=O)N4CCC(OC5=CC=CC=C5)CC4
Molecular Formula
C24H23N3O4S
Molecular Weight
449.52
References & Citations
[1]Liang J, et al. Synthesis and in vitro evaluation of benzo [b] thiophene-3-carboxylic acid 1, 1-dioxide derivatives as anticancer agents targeting the RhoA/ROCK pathway[J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2024, 39 (1) : 2390911.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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