(+) -DHMEQ
(+) -DHMEQ is an activator of antioxidant transcription factor Nrf2. (+) -DHMEQ is the enantiomer of (-) -DHMEQ. (-) -DHMEQ inhibits NF-kB than its enantiomer (+) -DHMEQ.
Product Specifications
CAS Number
287194-41-6
Product Name Alternative
(1R,2R,6R) -Dehydroxymethylepoxyquinomicin; (1R,2R,6R) -DHMEQ
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/__addition__-DHMEQ.html
Purity
98.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC([C@@H](O)[C@@]1([H])O[C@@]21[H])=CC2=O)C3=CC=CC=C3O
Molecular Formula
C13H11NO5
Molecular Weight
261.23
References & Citations
[1]Niitsu Y, et al. Chemoenzymatic synthesis of (2R,3R,4R) -dehydroxymethylepoxyquinomicin (DHMEQ), a newactivator of antioxidant transcription factor Nrf2. Org Biomol Chem. 2011 Jun 21;9 (12) :4635-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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