Dehydroglyasperin D

Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively) . Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi[1][2][3].

Product Specifications

CAS Number

[517885-72-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Aldose Reductase; COX

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dehydroglyasperin-d.html

Solubility

10 mM in DMSO

Smiles

OC1=CC=C(C2=CC3=C(OC)C(C/C=C(C)\C)=C(OC)C=C3OC2)C(O)=C1

Molecular Formula

C22H24O5

Molecular Weight

368.42

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Lee YS, et al. Aldose reductase inhibitory compounds from Glycyrrhiza uralensis. Biol Pharm Bull. 2010;33 (5) :917-21.|[2]Jung SK, et al. MLK3 is a novel target of dehydroglyasperin D for the reduction in UVB-induced COX-2 expression in vitro and in vivo. J Cell Mol Med. 2015 Jan;19 (1) :135-42.|[3]Baek EJ, et al. Dehydroglyasperin D Suppresses Melanin Synthesis through MITF Degradation in Melanocytes. J Microbiol Biotechnol. 2022 Aug 28;32 (8) :982-988.