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PTBP1-RNA-binding inhibitor P6 (TFA)

PTBP1-RNA-binding inhibitor P6 (PTBP1 α3-helix derived peptide P6) TFA is a stapled peptide inhibitor of the splicing factor PTBP1, which inhibits alternative splicing events regulated by PTBP1. PTBP1 binds RNA through its RNA recognition motif[1].

Product Specifications

Product Name Alternative

PTBP1 α3-helix derived peptide P6 (TFA)

UNSPSC

12352209

Target

DNA/RNA Synthesis

Type

Peptides

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ptbp1-rna-binding-inhibitor-p6-tfa.html

Purity

99.49

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

O=C(N[C@@H](CCC(N)=O)C(N[C@@](C)(CCC/C=C\CCC1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@]21C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@](CCC/C=C\CCC2)(C)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(N)=O)NC(C)=O.xO=C(O)C(F)(F)F

Molecular Formula

C72H120N22O19.xC2HF3O2

Molecular Weight

1597.86 (free base)

References & Citations

[1]Schmeing S, et al. Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding. Chem Sci. 2023 Jul 13;14 (31) :8269-8278.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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