LY2922470
LY2922470 is a selective and orally active agonist for the G protein-coupled receptor 40 (GPR40) . LY2922470 activates GPR40-mediated β-arrestin recruitment with EC50s of 7 nM (human GPR40), 1 nM (mouse GPR40) and 3 nM (rat GPR40) . LY2922470 can be used for research of type 2 diabetes mellitus (T2DM) [1].
Product Specifications
CAS Number
1423018-12-5
UNSPSC
12352005
Target
Free Fatty Acid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ly2922470.html
Purity
99.39
Solubility
DMSO : ≥ 125 mg/mL
Smiles
COC1=C(N(CC2=CC=C(COC3=CC=C([C@@H](C#CC)CC(O)=O)C=C3)S2)CCC4)C4=CC=C1
Molecular Formula
C28H29NO4S
Molecular Weight
475.60
References & Citations
[1]Hamdouchi C, et al. The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470) . J Med Chem. 2016 Dec 22;59 (24) :10891-10916.|[2]Hwang HJ, et al., AM1638, a GPR40-Full Agonist, Inhibited Palmitate- Induced ROS Production and Endoplasmic Reticulum Stress, Enhancing HUVEC Viability in an NRF2-Dependent Manner. Endocrinol Metab (Seoul) . 2023 Dec;38 (6) :760-769.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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