AG-13958 (mono(hydrochloride))
Product Specifications
UNSPSC Description
AG-13958 monohydrochloride, a potent VEGFR tyrosine kinase inhibitor, is used for treatment of choroidal neovascularization associated with age-related macular degeneration (AMD)[1].
Target Antigen
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ag-13958-mono-hydrochloride.html
Smiles
O=C(C1=CC(C)=NN1C)NC(C=C2NC3=CC=C4C(/C=C/C5=CC=CC=N5)=NNC4=C3)=C(C=C2)F.Cl
Molecular Weight
503.96
References & Citations
[1]M.B. Kosa, et al. Ocular and Systemic Pharmacokinetics of AG-013958 With Sub-Tenon Administration To Cynomologus Monkeys. Investigative Ophthalmology & Visual Science May 2005, Vol.46, 5379.|[2]Solowiej J, et al. Substrate-specific conformational regulation of the receptor tyrosine kinase VEGFR2 catalytic domain. ACS Chem Biol. 2013 May 17;8(5):978-86.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15492A/AG-13958-mono-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15492A/
Clinical Information
No Development Reported
CAS Number
319463-49-5
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