AG-13958 (mono (hydrochloride) )

AG-13958 monohydrochloride, a potent VEGFR tyrosine kinase inhibitor, is used for treatment of choroidal neovascularization associated with age-related macular degeneration (AMD) [1].

Product Specifications

CAS Number

[319463-49-5]

Product Name Alternative

AG-013958 (monohydrochloride)

UNSPSC

12352005

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ag-13958-mono-hydrochloride.html

Smiles

O=C(C1=CC(C)=NN1C)NC(C=C2NC3=CC=C4C(/C=C/C5=CC=CC=N5)=NNC4=C3)=C(C=C2)F.Cl

Molecular Formula

C26H23ClFN7O

Molecular Weight

503.96

References & Citations

[1]M.B. Kosa, et al. Ocular and Systemic Pharmacokinetics of AG-013958 With Sub-Tenon Administration To Cynomologus Monkeys. Investigative Ophthalmology & Visual Science May 2005, Vol.46, 5379.|[2]Solowiej J, et al. Substrate-specific conformational regulation of the receptor tyrosine kinase VEGFR2 catalytic domain. ACS Chem Biol. 2013 May 17;8 (5) :978-86.