Isorhamnetin-3-O-glucoside

Isorhamnetin-3-O-glucoside is an orally active natural compound. Isorhamnetin 3-O-glucoside increases P-ERK, ERK, P-Akt (Ser473), P-PI3K, and PDX-1. Isorhamnetin 3-O-glucoside downregulates C/EBPα and inhibits lipase. Isorhamnetin 3-O-glucoside reduces lipids and inhibits obesity[1][2][3][4][5].

Product Specifications

CAS Number

[5041-82-7]

UNSPSC

12352005

Target

Akt; ERK; Lipase; Others; PERK; PI3K

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/isorhamnetin-3-o-glucoside.html

Purity

99.96

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1C(O[C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO)=C(C3=CC(OC)=C(O)C=C3)OC4=CC(O)=CC(O)=C14

Molecular Formula

C22H22O12

Molecular Weight

478.40

References & Citations

[1]Le-yue Du, et al. Analysis of the Metabolites of Isorhamnetin 3-O-Glucoside Produced by Human Intestinal Flora in Vitro by Applying Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry. J Agric Food Chem. 201462122489-2495.|[2]Lee D, et al. In vitro studies to assess the α-glucosidase inhibitory activity and insulin secretion effect of isorhamnetin 3-o-glucoside and quercetin 3-o-glucoside isolated from Salicornia herbacea. Processes, 2021, 9 (3) : 483.|[3]Lee J H, et al. The beneficial effect of Salicornia herbacea extract and isorhamnetin-3-O-glucoside on obesity. Processes, 2023, 11 (4) : 977. |[4]Wang H, et al. Structures, Sources, Identification/Quantification Methods, Health Benefits, Bioaccessibility, and Products of Isorhamnetin Glycosides as Phytonutrients. Nutrients. 2023 Apr 18;15 (8) :1947. |[5]Antunes-Ricardo M, et al. Opuntia ficus-indica Extract and Isorhamnetin-3-O-Glucosyl-Rhamnoside Diminish Tumor Growth of Colon Cancer Cells Xenografted in Immune-Suppressed Mice through the Activation of Apoptosis Intrinsic Pathway. Plant Foods Hum Nutr. 2021 Dec;76 (4) :434-441.