Raseglurant

Raseglurant (ADX-10059) is a mGlu5 receptor negative allosteric modulator. Raseglurant is effective against migraine. Raseglurant reduces the Haloperidol (HY-14538) -induced catalepsy in mice[1][2].

Product Specifications

CAS Number

[757950-09-7]

Product Name Alternative

ADX-10059

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/raseglurant.html

Purity

99.65

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=C(C)C=C(C)N=C1C#CC2=CC=CC(F)=C2

Molecular Formula

C15H13FN2

Molecular Weight

240.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Romero-Fernandez W, et al. The mGlu5 Receptor Protomer-Mediated Dopamine D2 Receptor Trans-Inhibition Is Dependent on the Adenosine A2A Receptor Protomer: Implications for Parkinson's Disease. Mol Neurobiol. 2022 Oct;59 (10) :5955-5969. |[2]Font J, et al. Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator. Elife. 2018 Jan 8;7:e34752.