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Alkaline phosphatase, Bovine intestine

Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation[1][2][3][4][5][6].

Product Specifications

CAS Number

9001-78-9

Product Name Alternative

Apase

UNSPSC

12352204

Hazard Statement

H317

Target

Bacterial; Endogenous Metabolite; Glutathione Peroxidase; Phosphatase

Type

Enzyme

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/alkaline-phosphatase-bovine-intestine.html

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

[Alkalinephosphatase,Bovineintestine]

Precautions

H317

References & Citations

[1]Ujjawal Sharma, et al. Alkaline Phosphatase: An Overview. Indian J Clin Biochem. 2014 Jul; 29 (3) : 269-278.|[2]Chirambo GM, et al. The role of alkaline phosphatase in intracellular lipid accumulation in the human hepatocarcinoma cell line, HepG2. Exp Mol Pathol. 2017 Apr;102 (2) :224-229.|[3]Beumer C, et al. Calf intestinal alkaline phosphatase, a novel therapeutic drug for lipopolysaccharide (LPS) -mediated diseases, attenuates LPS toxicity in mice and piglets. J Pharmacol Exp Ther. 2003 Nov;307 (2) :737-44.|[4]van Veen SQ, et al. Bovine intestinal alkaline phosphatase attenuates the inflammatory response in secondary peritonitis in mice. Infect Immun. 2005 Jul;73 (7) :4309-14.|[5]Hyoju SK, et al. Intestinal alkaline phosphatase decreases intraperitoneal adhesion formation. J Surg Res. 2017 Feb;208:84-92. |[6]Martínez-Moya P, et al. Exogenous alkaline phosphatase treatment complements endogenous enzyme protection in colonic inflammation and reduces bacterial translocation in rats. Pharmacol Res. 2012 Aug;66 (2) :144-53.

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20°C for 2 years

Scientific Category

Enzyme

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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