(s) -PF-4136309

(s) -PF-4136309 is the isomer of PF-4136309 (HY-13245), and can be used as an experimental control. PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.

Product Specifications

CAS Number

[1372407-07-2]

Product Name Alternative

(s) -INCB8761

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CCR; Drug Isomer

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/s-pf-4136309.html

Concentration

10mM

Purity

98.93

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O[C@]1(CC[C@@](CC1)([H])N[C@@H]2CN(CC2)C(CNC(C3=CC=CC(C(F)(F)F)=C3)=O)=O)C4=NC=C(C=C4)C5=NC=CC=N5

Molecular Formula

C29H31F3N6O3

Molecular Weight

568.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Xue CB, et al. Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist. ACS Med. Chem. Lett., 2011, 2 (12), pp 913-918.