(s)-PF-4136309
Product Specifications
Product Name Alternative
(s)-INCB8761
UNSPSC Description
(s)-PF-4136309 is the isomer of PF-4136309 (HY-13245), and can be used as an experimental control. PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s-pf-4136309.html
Purity
98.93
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O[C@]1(CC[C@@](CC1)([H])N[C@@H]2CN(CC2)C(CNC(C3=CC=CC(C(F)(F)F)=C3)=O)=O)C4=NC=C(C=C4)C5=NC=CC=N5
Molecular Weight
568.59
References & Citations
[1]Xue CB, et al. Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist. ACS Med. Chem. Lett., 2011, 2 (12), pp 913-918.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13245A/s-PF-4136309-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13245A/s-PF-4136309-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1372407-07-2
Available Sizes
Curated Selection
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