ABBV-467
Product Specifications
UNSPSC Description
ABBV-467 is a selective MCL-1 inhibitor (Ki: apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma[1].
Target Antigen
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/abbv-467.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)[C@@H](CC1=CC2=CC=C1OCC3=NC(C4=CC=C(OC[C@H]5OCCOC5)C=C4)=NC=C3)OC6=NC=NC7=C6C(C8=C(C)C(Cl)=C(O[C@@H](CO2)CN9CCN(C)CC9)C(Cl)=C8C)=C(C%10=CC=C(F)C=C%10)S7
Molecular Weight
1037.98
References & Citations
[1]Yuda J, et al. Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond). 2023 Oct 25;3(1):154.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149672/ABBV-467-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149672/ABBV-467-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
2287186-66-5
Available Sizes
Curated Selection
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