ABBV-467

ABBV-467 is a selective MCL-1 inhibitor (Ki: apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma[1].

Product Specifications

CAS Number

[2287186-66-5]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/abbv-467.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)[C@@H](CC1=CC2=CC=C1OCC3=NC(C4=CC=C(OC[C@H]5OCCOC5)C=C4)=NC=C3)OC6=NC=NC7=C6C(C8=C(C)C(Cl)=C(O[C@@H](CO2)CN9CCN(C)CC9)C(Cl)=C8C)=C(C%10=CC=C(F)C=C%10)S7

Molecular Formula

C53H51Cl2FN6O9S

Molecular Weight

1037.98

References & Citations

[1]Yuda J, et al. Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond) . 2023 Oct 25;3 (1) :154.