WLB-89462
WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM) . WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents) [1].
Product Specifications
CAS Number
2849471-75-4
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/wlb-89462.html
Purity
98.70
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CN1CCC(CC1)C2=C(C3=CC(C)=NO3)C=NC(CC)=N2)N4CCOCC4
Molecular Formula
C21H29N5O3
Molecular Weight
399.49
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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