RGLS4326 (sodium)
RGLS4326 sodium is a first-in-class, short oligonucleotide inhibitor of microRNA-17 (miR-17) . RGLS4326 sodium can be used for the research of autosomal dominant polycystic kidney disease (ADPKD) . RGLS4326 sodium inhibits miR-17 function in HeLa cells with an EC50 value of 28.3 nM[1].
Product Specifications
Product Name Alternative
RG4326 (sodium)
UNSPSC
12352208
Target
MicroRNA
Type
Oligonucleotides
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rgls4326-sodium.html
Purity
99.67
Solubility
10 mM in H2O
Smiles
[RGLS4326(sodium)]
Molecular Weight
3082.42 (free acid)
References & Citations
[1]Edmund C Lee, et al. Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease. Nat Commun. 2019 Sep 12;10 (1) :4148.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 1
Available Sizes
Curated Selection
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