RGLS4326 (sodium)

RGLS4326 sodium is a first-in-class, short oligonucleotide inhibitor of microRNA-17 (miR-17) . RGLS4326 sodium can be used for the research of autosomal dominant polycystic kidney disease (ADPKD) . RGLS4326 sodium inhibits miR-17 function in HeLa cells with an EC50 value of 28.3 nM[1].

Product Specifications

Product Name Alternative

RG4326 (sodium)

UNSPSC

12352208

Target

MicroRNA

Type

Oligonucleotides

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rgls4326-sodium.html

Purity

99.67

Solubility

10 mM in H2O

Smiles

[RGLS4326(sodium)]

Molecular Weight

3082.42 (free acid)

References & Citations

[1]Edmund C Lee, et al. Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease. Nat Commun. 2019 Sep 12;10 (1) :4148.