(3R,10R,14aS)-AZD4625
Product Specifications
UNSPSC Description
(3R,10R,14aS)-AZD4625 is the isomer of AZD4625 (HY-146223), and can be used as an experimental control. AZD4625 (Compound 21) is a highly potent, selective, covalent and allosteric inhibitor of the mutant GTPase KRASG12C. AZD4625 has high oral bioavailability[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3r-10r-14as-azd4625.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
C=CC(N1C[C@H]2N(C3=C4C(OCC2)=C(Cl)[C@]([C@]5=C(F)C=CC=C5O)=C(F)C4=NC=N3)C[C@H]1C)=O
Molecular Weight
486.90
References & Citations
[1]Kettle JG, et al. Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C. J Med Chem. 2022 May 12;65(9):6940-6952.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146223A/3R-10R-14aS-AZD4625-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146223A/
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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