DdGTP (trisodium)

DdGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddGTP trisodium acts as an inhibitor or a substrate for DNA polymerase α[1][2][3].

Product Specifications

Product Name Alternative

2′,3′-Dideoxyguanosine 5′-triphosphate (trisodium)

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ddgtp-trisodium.html

Concentration

100 mM * 50 μL in Water

Purity

98.01

Solubility

10 mM in DMSO

Smiles

O=[P](O[P](O[P](O)(O[Na])=O)(O[Na])=O)(O[Na])OC[C@@H]1CC[C@H](N2C(NC(N)=NC3=O)=C3N=C2)O1

Molecular Formula

C10H13N5Na3O12P3

Molecular Weight

557.13

References & Citations

[1]Debyser Z, et al. Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2 (1H) -thion e, and 1-[ (2-hydroxyethoxy) methyl]-6- (phenylthio) thymine derivatives. J Biol Chem. 1992 Jun 15;267 (17) :11769-76.|[2]Ono K, et al. Utilization of 2',3'-dideoxyguanosine 5'-triphosphate as an inhibitor and substrate for DNA polymerase alpha. Biomed Pharmacother. 1990;44 (2) :115-21.|[3]Z G Chidgeavadze, et al. 3'-Fluoro-2',3'-dideoxyribonucleoside 5'-triphosphates: terminators of DNA synthesis. FEBS Lett. 1985 Apr 22;183 (2) :275-8.