Alkyne Cholesterol

Alkyne Cholesterol, a modified lipid, is a click chemistry reagent containing an alkyne group. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents in the presence of a copper (Cu) -containing catalyst. Alkyne Cholesterol can be used for tracking cellular cholesterol metabolism and localization[1][2][3].

Product Specifications

CAS Number

[1631985-09-5]

UNSPSC

12352211

Target

Liposome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/alkyne-cholesterol.html

Purity

95.56

Solubility

Ethanol : 12.5 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC#C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C

Molecular Formula

C26H40O

Molecular Weight

368.60

References & Citations

[1]Katherine Windsor, et al. Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome. J Lipid Res. 2013 Oct;54 (10) :2842-50. |[2]Katherine Windsor, et al. Assay of protein and peptide adducts of cholesterol ozonolysis products by hydrophobic and click enrichment methods. Chem Res Toxicol. 2014 Oct 20;27 (10) :1757-68.|[3]Alkyne Cholesterol.