Anti-Insulin receptor (α subunit) Antibody

Mouse Monoclonal Antibody specific to Insulin receptor

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

IR, EC 2.7.10.1, CD antigen CD220 [Cleaved into: Insulin receptor subunit α; Insulin receptor subunit beta]

Gene Name

INSR

NCBI Gene ID

UniProt

P06213

Cellular Locus

Cell membrane, Late endosome, Lysosome

Host

Mouse

Reactivity

Human

Immunogen

IM-9 lymphocytes

Target Antigen

Insulin receptor

Target

Insulin receptor (α subunit)

Clonality

Monoclonal

Isotype

IgG2a

Type

Antibody

Applications

IP, Inhibition, Activation, Stimulation, WB

Field of Research

Growth Factors, Cytokines, Receptors

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically rUniProtKB:P15208, PubMed:12138094, PubMed:16314505, PubMed:16831875, PubMed:8257688, PubMed:8276809, PubMed:8452530, PubMed:9428692}.