PF-431396

N-methyl-N-[2-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide

Tyrosine Kinase FAK TGF-β Smad Signaling Pyk2 Tyrosine Kinase Pyk2

0.989

A solid

insoluble in H2O; insoluble in EtOH; ≥18.1 mg/mL in DMSO

CN(C1=CC=CC=C1CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C

C22H21F3N6O3S

506.5

Blue ice

Store at -20°C.

717906-29-1