Tankyrase Inhibitors (TNKS) 49

N-((1r,4r)-4-(4-cyanophenoxy)cyclohexyl)-3-((4-oxo-3,4-dihydroquinazolin-2-yl)thio)propanamide

TNKS 49;TNKS49;TNKS-49

Chromatin Epigenetics PARP DNA Damage DNA Repair PARP Stem Cell Wnt β-catenin

0.9808

A solid

≥22.45 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

O=C1NC(SCCC(N[C@H]2CC[C@H](OC3=CC=C(C#N)C=C3)CC2)=O)=NC4=CC=CC=C41

C24H24N4O3S

448.54

Blue ice

Store at -20°C.