SORT-PGRN interaction inhibitor 1
SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC50 of 2 μM[1].
Product Specifications
CAS Number
[100957-85-5]
Product Name Alternative
BMS-387032,Mutagenic Impurity of Tenofovir Disoproxil (Standard); Tenofovir Impurity 2 (Standard)
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Neurotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sort-pgrn-interaction-inhibitor-1.html
Purity
99.37
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C(C)(C)C)=NN1CC2=CC=CC=C2)O
Molecular Formula
C15H18N2O2
Molecular Weight
258.32
Precautions
H302, H312, H332
References & Citations
[1]Shawn J Stachel, et al. Identification of potent inhibitors of the sortilin-progranulin interaction. Bioorg Med Chem Lett. 2020 Sep 1;30 (17) :127403.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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