LDK378

1032900-25-6

5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine

LDK 378;LDK-378;Ceritinib

Tyrosine Kinase ALK

0.9973

insoluble in H2O; ≥13.95 mg/mL in DMSO; ≥4.62 mg/mL in EtOH with gentle warming

CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl

C28H36ClN5O3S

558.14

Blue ice

Store at -20°C.