Neratinib (HKI-272)
HER2/EGFR inhibitor,potent and irreversible
Product Specifications
Product Name Alternative
(E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
Sequence
HKI-272;HKI272;HKI 272
Field of Research
JAK STAT Signaling EGFR Tyrosine Kinase EGFR Tyrosine Kinase HER2
Purity
0.9981
Form
A solid
Solubility
insoluble in H2O; ≥13.93 mg/mL in DMSO with gentle warming; ≥2.52 mg/mL in EtOH with gentle warming
Smiles
CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C
Molecular Formula
C30H29ClN6O3
Molecular Weight
557.04
Shipping Conditions
Blue ice
Storage Conditions
Store at -20°C.
CAS Number
698387-09-6
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