Neratinib (HKI-272)

698387-09-6

(E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide

HKI-272;HKI272;HKI 272

JAK STAT Signaling EGFR Tyrosine Kinase EGFR Tyrosine Kinase HER2

0.9981

A solid

insoluble in H2O; ≥13.93 mg/mL in DMSO with gentle warming; ≥2.52 mg/mL in EtOH with gentle warming

CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C

C30H29ClN6O3

557.04

Blue ice

Store at -20°C.